How meds in water could impact human cells

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But these studies haven’t used water samples analyzed for drugs. Instead, the studies estimate danger from what’s known about how much of a drug is sold and how toxic it is to animals. Then, safety margins are added for unknowns, such as possible effects of decades of exposure.

Those margins are just educated guesses. Also, the studies usually ignore what might happen to people exposed to the complex combinations of medicines that are often found in drinking water.

Then, there are the byproducts of the drugs. When medications are digested and processed through water treatment plants, they may take a new metabolic form.

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“They miss some of the big issues. Our research shows mixtures are so prevalent,” said Dana Kolpin, a U.S. Geological Survey water expert who launched a plethora of research in 2002 after finding pharmaceuticals in most samples taken from 139 streams in 30 states. “If there are any cumulative or additive issues, you can’t just dismiss things so quickly.”

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Even if Kolpin is right, the industry may be focusing on the wrong pharmaceuticals, said chemist James Shine at the Harvard School of Public Health, who oversaw what’s probably the broadest risk review yet, a yet-to-be-published study covering scores of the most common drugs sold in the United States.

As suspected, some chemotherapy drugs turn up high on that list. But blood-pressure diuretics, though rarely considered, appear to pose more risk than many drugs more often evaluated.

Even when researchers downplay risk, that may not be the final word.

People “are going to be concerned about being medicated by mandate when you turn on the tap,” said Dr. Stevan Gressitt, a psychiatrist who’s led a push for a program in Maine that allows consumers to turn in unused pharmaceuticals for secure disposal or destruction. “And that’s going to be seen if the level is (only) one molecule in 100 taps.”

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